Zinc supplementation for treating diarrhea in children: a systematic review and meta-analysis.
نویسندگان
چکیده
OBJECTIVE To update the available evidence about zinc use for treating diarrhea in children and to assess its effect on the malnourished population, a subgroup that has not been fully explored in previous analyses. METHODS A systematic review was performed of randomized clinical trials that assessed children up to 5 years old with acute diarrhea who received zinc supplementation. Controls received a placebo or oral rehydration therapy. After searching the main databases, without language restrictions, two independent reviewers selected eligible studies, extracted the data, and assessed the risk of bias of included studies. Meta-analyses were calculated using Mantel-Haenszel or inverse variance random effects. RESULTS Eighteen of 1 041 studies retrieved were included in the review (n = 7 314 children). Zinc was beneficial for reducing the duration of diarrhea in hours (mean difference [MD] = -20.12, 95% confidence interval [CI] = -29.15 to -11.09, I² = 91%). The effect was greater in malnourished children (MD = -33.17, 95% CI = -33.55 to -27.79, I² = 0%). Diarrhea prevalence on days 3, 5, and 7 was lower in the zinc group. The incidence of vomiting was significantly greater in the group that received zinc than in the control group. Included randomized controlled trials were of low risk of bias in most domains assessed. CONCLUSIONS Oral zinc supplementation significantly decreases diarrhea duration and has a greater effect on malnourished children. Zinc supplementation seems to be an appropriate public health strategy, mainly in areas of endemic deficiencies.
منابع مشابه
Oral Zinc Supplementation for the Treatment of Acute Diarrhea
Introduction: Diarrheal diseases are a serious health problem and important causes of growth retardation and death in the developing world, especially those of prolonged duration. Since diarrhea is constantly found in children with zinc deficiency, very studies supported zinc supplements beneficial on the duration and severity of diarrhea among children. We review the impact of zinc effects on ...
متن کاملTherapeutic Value of Zinc Supplementation in Acute and Persistent Diarrhea: A Systematic Review
BACKGROUND For over a decade, the importance of zinc in the treatment of acute and persistent diarrhea has been recognized. In spite of recently published reviews, there remain several unanswered questions about the role of zinc supplementation in childhood diarrhea in the developing countries. Our study aimed to assess the therapeutic benefits of zinc supplementation in the treatment of acute ...
متن کاملWhat zinc supplementation does and does not achieve in diarrhea prevention: a systematic review and meta-analysis
BACKGROUND Prevention of diarrhea has presented indomitable challenges. A preventive strategy that has received significant interest is zinc supplementation. Existing literature including quantitative meta-analyses and systematic reviews tend to show that zinc supplementation is beneficial however evidence to the contrary is augmenting. We therefore conducted an updated and comprehensive meta-a...
متن کاملSerum, hair and nail Zinc level in children with asthma; zinc supplemental treatment in children with asthma: a systematic and meta-analysis review article
متن کامل
Zinc supplementation in children is not associated with decreases in hemoglobin concentrations.
Zinc supplementation has proven beneficial in the treatment of acute child diarrhea and appears to enhance linear growth. There is a theoretical risk of anemia in zinc-supplemented children due to inhibited iron transport via decreased copper absorption. Although many zinc supplementation trials have included hematological measures, the potential effect of zinc on these outcomes has not been qu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Revista panamericana de salud publica = Pan American journal of public health
دوره 33 5 شماره
صفحات -
تاریخ انتشار 2013